LOCALISED DYNACTIN PROTECTS GROWING MICROTUBULES TO DELIVER OSKAR MRNA TO THE POSTERIOR CORTEX OF THE DROSOPHILA OOCYTE

Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines Organizers where the abdomen and germ cells form in the embryo.Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non-centrosomal microtubule organising centres (ncMTOCs) along the anterior/lateral cortex.

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Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion.

Intestinal L-cells sense glucose and other nutrients, and in response release glucagon-like peptide 1 (GLP-1), peptide YY and other hormones with anti-diabetic and weight-reducing effects.The stimulus-secretion pathway in L-cells is still poorly understood, although it is known that GLP-1 secreting cells use sodium-glucose co-transporters (SGLT) an

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